A CANCER RESEARCHER & NANOMEDICINE SPECIALIST
My research focuses on oncology, cancer immunology, and nanomedicine, specializing in targeted therapy and tumor microenvironment analysis for triple-negative breast and ovarian cancers. I am dedicated to advancing translational research and developing novel nanochemotherapeutic strategies to improve therapeutic outcomes.
Citations
h-index
i10-index
Projects Won
ADVANCING TRANSLATIONAL CANCER RESEARCH THROUGH TARGETED THERAPIES, NANOMEDICINE, AND INNOVATIVE DISCOVERIES IN TUMOR BIOLOGY.
Hi there! I’m Dr. Zeeshan Ahmad Bhutta, a dedicated cancer researcher specializing in oncology, cancer immunology, and nanomedicine. With extensive experience in experimental oncology, my work focuses on targeted drug delivery systems and tumor microenvironment analysis to address aggressive malignancies like triple-negative breast and ovarian cancers.
I specialize in evaluating novel therapeutic agents using advanced techniques including flow cytometry, immunofluorescence, Western blotting, and automated microscopy. Currently, my research at Xiamen University focuses on constructing peptide-coated nanochemotherapeutics for hepatocellular carcinoma theranostics.
What I Do
TARGETED CANCER THERAPIES
Investigating phytochemicals and novel therapeutic agents against triple-negative breast, ovarian, and endometrial cancers.
NANOMEDICINE & DRUG DELIVERY
Designing nanochemotherapeutics and functionalized nanocomposites for enhanced drug delivery and theranostics.
TUMOR MICROENVIRONMENT
Analyzing mechanisms of epithelial-mesenchymal transition (EMT), metastasis, and mitochondrial ROS modulation.
APOPTOSIS & AUTOPHAGY
Exploring cell death pathways and drug resistance mechanisms to improve overall therapeutic efficacy.
EXPERIMENTAL ONCOLOGY
Utilizing advanced in vitro culturing, automated microscopy, flow cytometry, and molecular biology techniques.
ONE HEALTH & TOXICOLOGY
Evaluating animal models for translational cancer research, toxicological impacts, and global health interventions.
EXPLORE SELECTED RESEARCH PUBLICATIONS AND PROJECTS ADVANCING CANCER THERAPEUTICS, NANOMEDICINE, AND TARGETED THERAPIES.
- Bhutta, Z.A., Kim, D.H., Lee, H.K., and Choi, K.-C. (2026), Evaluation of Punicalagin as a Multi-Targeted Therapeutic Agent Against Endometrial Cancer. International Journal of Oncology, 69, 109. https://doi.org/10.3892/ijo.2026.5922
- Ahn, S.H., Bhutta, Z.A., Na, H., Lee, H.K., and Choi, K.-C. (2026), Anti-cancer effects of tangeretin in cervical cancer through reactive oxygen species-induced mitochondrial dysfunction and apoptosis. Oncology Reports, 56, 166. https://doi.org/10.3892/or.2026.9171
- Bhutta, Z.A., Kim, C.-W., Na, H., Lee, H.K., and Choi, K.-C. (2026), Punicalagin Inhibits the Growth and Proliferation of Ovarian Epithelial Adenocarcinoma Cells Via Apoptosis and Autophagic Cell Death. Journal of Biochemical and Molecular Toxicology, 40, e70908. https://doi.org/10.1002/jbt.70908
- Bhutta, Z. A., Kim, C. W. & Choi, K.-C. (2025). Punicalagin Attenuates Benzo[α]pyrene-Induced Metastasis by Reversing Epithelial-Mesenchymal Transition via Mitochondrial ROS Modulation in Triple-Negative Breast Cancer Cells. Toxicological Research. https://doi.org/10.1007/s43188-026-00338-y
- Jeon, S.Y., Bhutta, Z.A†., Lee, H. K. & Choi, K.-C. (2026). Inhibitory effect of progesterone on breast cancer progression and migration via the regulation of epithelial-mesenchymal transition. Oncology Research. https://doi.org/10.32604/or.2026.071328
- Jeoung, Y. H., Lee, H. K., Ahn, S. H., Bhutta, Z. A., & Choi, K.-C. (2025). Tangeretin induces apoptosis and cell cycle arrest in thyroid cancer cells. Toxicological Research, 1-12. https://doi.org/10.1007/s43188-025-00293-0
- Shoaib, M., Bhutta, Z. A†., Javed, A., Amjad, M. N., Li, W., Choi, K.-C., & Pu, W. Future of PARP inhibitors in cancer treatment: overcoming resistance and enhancing efficacy with combination therapies. Journal of Zhejiang University SCIENCE B. https://doi.org/10.1631/jzus.B2400146
- Bhutta, Z. A., & Choi, K.-C. (2025). Canine mammary tumors as a promising adjunct preclinical model for human breast cancer research: similarities, opportunities, and challenges. Archives of Pharmacal Research, 48(1), 43-61. https://doi.org/10.1007/s12272-024-01524-y
- Bhutta, Z. A., & Choi, K. C. (2025). Phytochemicals as Novel Therapeutics for Triple-Negative Breast Cancer: A Comprehensive Review of Current Knowledge. Phytotherapy Research, 39(1), 364-396. https://doi.org/10.1002/ptr.8376
- Bhutta, Z. A., Go, R. E., & Choi, K. C. (2024). Effect of punicalagin on the autophagic cell death in triple-negative breast cancer cells. Toxicological Research, 40(4), 585-598. https://doi.org/10.1007/s43188-024-00246-z
- Kulyar, M. F.-A., Mo, Q., Yao, W., Li, Y., Nawaz, S., Loon, K. S., Ahmed, A. E., Alsaegh, A. A., Al Syaad, K. M., Akhtar, M., Bhutta, Z. A., Li, J., & Qi, D. (2024). Modulation of apoptosis and Inflammasome activation in chondrocytes: co-regulatory role of Chlorogenic acid. Cell Communication and Signaling, 22(1). https://doi.org/10.1186/s12964-023-01377-w
- Bhutta, Z. A., & Choi, K.-C. (2023). Antitumor Effects of Dietary Compounds. Nutrients, 15(10), 2349. https://www.mdpi.com/2072-6643/15/10/2349
- Shoaib, M., Aqib, A. I., Muzammil, I., Majeed, N., Bhutta, Z. A., Kulyar, M. F.-A., Fatima, M., Zaheer, C.-N. F., Muneer, A., Murtaza, M., Kashif, M., Shafqat, F., & Pu, W. (2023). MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework. Frontiers in Microbiology, 13. https://doi.org/10.3389/fmicb.2022.1067284
- Bhutta, Z. A., Kanwal, A., Ali, M., Kulyar, M. F.-e.-A., Yao, W., Shoaib, M., Ashar, A., Mahfooz, A., Ijaz, M., Ijaz, N., Asif, M., Nawaz, S., Mahfooz, M. R., & Kanwal, T. (2021). Emerging nanotechnology role in the development of innovative solutions against COVID-19 pandemic. Nanotechnology, 32(48), 482001. https://doi.org/10.1088/1361-6528/ac189e
- Bhutta, Z. A., Kulyar, M. F.-e.-A., Kanwal, A., Mahfooz, A., Ali, M., & Li, K. (2021). One Health: An inclusive framework to curb the COVID-19 pandemic. EXCLI Journal, 20, 724-726. https://doi.org/10.17179/excli2021-3615
- Bhutta, Z. A., Ashar, A., Mahfooz, A., Khan, J. A., Saleem, M. I., Rashid, A., Aqib, A. I., Kulyar, M. F.-e.-A., Sarwar, I., Shoaib, M., Nawaz, S., & Yao, W. (2021). Enhanced wound healing activity of nano ZnO and nano Curcuma longa in third-degree burn. Applied Nanoscience, 11(4), 1267-1278. https://doi.org/10.1007/s13204-020-01661-y
Postdoctoral Researcher
School of Public Health, Xiamen University, China
PhD Functional Veterinary Medicine
Chungbuk National University, Republic of Korea
Pg. Dip. One Health
University of Edinburgh, UK
MPhil Clinical Medicine and Surgery
University of Agriculture, Faisalabad, Pakistan
DVM
University of Bahawalpur, Pakistan
Targeted Cancer Therapies Nanomedicine & Theranostics Tumor Microenvironment Cancer Immunology Apoptosis & Autophagy Experimental Oncology
